The Tropomyosin-1 Rabbit Monoclonal Antibody (CAB8723) is a valuable tool for research involving tropomyosin-1, a protein that plays a crucial role in muscle contraction and overall cell stability. This antibody, generated using rabbit monoclonal technology, demonstrates high specificity and sensitivity when detecting tropomyosin-1 in human samples, making it ideal for use in Western blot applications.Tropomyosin-1 is essential for regulating the interaction between actin and myosin, key components of the muscle contraction process. Dysregulation of tropomyosin-1 has been implicated in various diseases, including cancer and cardiovascular disorders.
By utilizing this monoclonal antibody, researchers can further investigate the function and expression of tropomyosin-1 in different cell types, leading to new insights into its role in health and disease.Overall, the Tropomyosin-1 Rabbit Monoclonal Antibody (CAB8723) offers a reliable and effective solution for studying tropomyosin-1 in research areas such as muscle biology, cancer biology, and cardiovascular physiology. Its high specificity and sensitivity make it a valuable tool for gaining a better understanding of the molecular mechanisms involving tropomyosin-1 and its impact on cellular function.
Product Name:
Tropomyosin 1 Rabbit Monoclonal Antibody
SKU:
CAB8723
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 185-284 of human Tropomyosin 1 (P09493).
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y.
Purification Method:
Affinity purification
Gene ID:
7168
Clone Number:
ARC1283
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Tropomyosin 1 Rabbit mAb (CAB8723) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
