Tropomyosin 1 Rabbit Monoclonal Antibody (CAB8723)
- SKU:
- CAB8723
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | Tropomyosin 1 Rabbit Monoclonal Antibody |
SKU: | CAB8723 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 185-284 of human Tropomyosin 1 (P09493). |
Sequence: | LSEG KCAE LEEE LKTV TNNL KSLE AQAE KYSQ KEDR YEEE IKVL SDKL KEAE TRAE FAER SVTK LEKS IDDL EDEL YAQK LKYK AISE ELDH ALND MTSI |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 400μg-600μg extracts of whole cells |
Synonyms: | CMH3; TMSA; CMD1Y; LVNC9; C15orf13; HEL-S-265; HTM-alpha; Tropomyosin 1 |
Positive Sample: | Mouse skeletal muscle,Mouse heart,Rat skeletal muscle,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, cytoskeleton. |
Calculated MW: | 33kDa |
Observed MW: | 32、35、36、41kDa |
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y.
Purification Method: | Affinity purification |
Gene ID: | 7168 |
Clone Number: | ARC1283 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |