The TRKC Monoclonal Antibody is a vital tool for researchers studying TRKC, a receptor tyrosine kinase involved in the development and function of the nervous system. This antibody, produced in mice, displays high specificity and sensitivity for TRKC in human samples and is recommended for use in immunohistochemistry and flow cytometry applications.TRKC, also known as neurotrophic tyrosine kinase receptor type 1, plays a crucial role in neuronal survival, differentiation, and growth. Dysregulation of TRKC signaling has been implicated in various neurological disorders such as Alzheimer's disease and Parkinson's disease, making it a promising target for therapeutic interventions.
The TRKC Monoclonal Antibody allows for the detection and analysis of TRKC expression in different cell types, providing valuable insights into its function and potential implications in neurobiology and neurodegenerative diseases. Researchers can utilize this antibody to further understand the intricate mechanisms of TRKC signaling pathways and develop innovative treatment strategies for neurological conditions.
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4916
Clone Number:
ARC59398
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of Mouse brain, using TrKC antibody (CAB23002) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
