The TrkB Monoclonal Antibody (CAB21232) is a powerful tool for research involving the TrkB receptor, a key player in neural development and function. This antibody, produced through a monoclonal antibody development process, specifically targets the TrkB protein, allowing for precise detection and analysis in various cell types and tissues.TrkB, also known as tropomyosin receptor kinase B, is essential for neuronal survival, differentiation, and synaptic plasticity. Dysregulation of TrkB signaling has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and depression.
The TrkB Monoclonal Antibody is validated for use in applications such as immunohistochemistry and flow cytometry, making it a valuable tool for researchers studying neurobiology and neurodegenerative diseases.By understanding the function and regulation of the TrkB receptor, researchers can gain insights into the mechanisms underlying neurological disorders and potentially identify new therapeutic targets for the treatment of these conditions. The TrkB Monoclonal Antibody is a reliable and specific tool for advancing research in this critical area of neuroscience.
Product Name:
TrkB Monoclonal Antibody
SKU:
CAB21232
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 32-430 of human TrkB (NP_001018074.1).
Cell membrane, Endosome membrane, Single-pass type I membrane protein.
Calculated MW:
92kDa
Observed MW:
90kDa/140kDa
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4915
Clone Number:
ARC53486
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TrkB antibody (CAB21232) at 1:10000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
