TrkA Rabbit Monoclonal Antibody (CAB4147)
- SKU:
- CAB4147
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | TrkA Rabbit Monoclonal Antibody |
SKU: | CAB4147 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 697-796 of human TrkA (P04629). |
Sequence: | ESIL YRKF TTES DVWS FGVV LWEI FTYG KQPW YQLS NTEA IDCI TQGR ELER PRAC PPEV YAIM RGCW QREP QQRH SIKD VHAR LQAL AQAP PVYL DVLG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; TrkA |
Positive Sample: | Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Early endosome membrane, Late endosome membrane, Single-pass type I membrane protein. |
Calculated MW: | 87kDa |
Observed MW: | 140kDa |
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Purification Method: | Affinity purification |
Gene ID: | 4914 |
Clone Number: | ARC0906 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |