The TRKA Rabbit Monoclonal Antibody (CAB4147) is a cutting-edge research tool designed for the study of TRKA, a receptor involved in nerve growth factor signaling pathways. This highly specific antibody, generated using rabbit monoclonal technology, is optimized for use in a variety of applications including Western blot, immunohistochemistry, and flow cytometry.TRKA, also known as NTRK1, is a key player in neuronal development and function, making it a crucial target for research in neurology, neurodevelopmental disorders, and cancer biology. The TRKA Rabbit Monoclonal Antibody (CAB4147) binds specifically to TRKA protein, enabling accurate detection and quantification in various sample types.
The role of TRKA in promoting neuronal survival and differentiation, as well as its involvement in tumorigenesis and cancer progression, underscores the importance of studying this receptor in diverse biological contexts. By utilizing the TRKA Rabbit Monoclonal Antibody (CAB4147), researchers can gain valuable insights into the mechanisms underlying TRKA signaling pathways, paving the way for the development of novel therapeutic strategies targeting TRKA-related diseases.
Product Name:
TrkA Rabbit Monoclonal Antibody
SKU:
CAB4147
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 697-796 of human TrkA (P04629).
Cell membrane, Early endosome membrane, Late endosome membrane, Single-pass type I membrane protein.
Calculated MW:
87kDa
Observed MW:
140kDa
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Purification Method:
Affinity purification
Gene ID:
4914
Clone Number:
ARC0906
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TrkA Rabbit mAb (CAB4147) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
