The TRK Fused Gene (TFG) Polyclonal Antibody (AB10001) is a crucial tool for researchers studying the TFG gene, which is involved in various cellular processes including growth regulation and cellular signaling. The antibody, produced using rabbits, exhibits high specificity towards human samples and is validated for use in immunohistochemistry and immunofluorescence applications. By targeting the TFG protein, this antibody allows for precise detection and analysis in a wide range of cell types, making it an invaluable resource for investigations in oncology and molecular biology.
TFG, a fusion gene resulting from chromosomal translocation events, has been implicated in the development and progression of certain cancers, particularly in solid tumors and hematological malignancies. Understanding the function of TFG is essential for unraveling its role in tumorigenesis and identifying potential therapeutic targets for cancer treatment. The TFG Polyclonal Antibody provides researchers with the means to explore the mechanisms underlying TFG-mediated oncogenesis and may lead to the development of innovative cancer therapies in the future.
Product Name:
TRK fused gene (TFG) Polyclonal Antibody
SKU:
CAB21329
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human TRK fused gene (TFG) (NP_006061.2).
cytoplasm, cytosol, endoplasmic reticulum exit site
Calculated MW:
43kDa
Observed MW:
Refer to figures
There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10342
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TRK fused gene (TRK fused gene (TFG)) antibody (CAB21329) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
