The TRIP4 Polyclonal Antibody (CAB15352) is a vital tool for researchers studying the TRIP4 protein, which plays a critical role in gene regulation and chromatin remodeling. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the TRIP4 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable asset for studies in molecular biology and epigenetics.TRIP4 is known for its involvement in transcriptional regulation and its interaction with various transcription factors and coactivators, making it an essential player in gene expression control.
Understanding the functions and mechanisms of TRIP4 is crucial for unraveling complex gene regulatory networks and exploring potential therapeutic targets in cancer, developmental disorders, and other diseases. The TRIP4 Polyclonal Antibody provides researchers with a powerful tool to investigate the role of TRIP4 in these contexts and advance our understanding of gene regulation processes.
Product Name:
TRIP4 Rabbit Polyclonal Antibody
SKU:
CAB15352
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 282-581 of human TRIP4 (NP_057297.2).
This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1).
Purification Method:
Affinity purification
Gene ID:
9325
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRIP4 Rabbit pAb (CAB15352) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
