The TRIM55 Polyclonal Antibody (CAB15917) is a valuable tool for researchers studying TRIM55, a protein involved in cellular processes such as protein degradation and immune response regulation. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TRIM55 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it suitable for studies in immunology and cancer research.
TRIM55 is known for its role in intracellular protein degradation and its involvement in immune system regulation. It has been implicated in various diseases, including cancer and autoimmune disorders, making it a target of interest for researchers looking to understand its impact on disease pathology. Investigating the function of TRIM55 is essential for developing new therapies that can modulate immune responses and potentially treat a range of conditions.
Antibody Name:
Anti-TRIM55 Antibody
Antibody SKU:
CAB15917
Antibody Size:
20uL, 50uL, 100uL
Application:
WB
Reactivity:
Human, Mouse
Host Species:
Rabbit
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 183-452 of human TRIM55 (NP_908974.1).
Application:
WB
Recommended Dilution:
WB 1:500 - 1:2000
Reactivity:
Human, Mouse
Positive Samples:
LO2, HepG2, Mouse skeletal muscle
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 183-452 of human TRIM55 (NP_908974.1).
Purification Method:
Affinity purification
Storage Buffer:
Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described.
UniProt Protein Function:
TRIM55: May regulate gene expression and protein turnover in muscle cells. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; Ligase
Chromosomal Location of Human Ortholog: 8q13.1
Molecular Function:identical protein binding; protein binding
NCBI Summary:
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Muscle-specific RING finger protein 2; MuRF-2; MuRF2; RING finger protein 29
Protein Family:
Tripartite motif-containing protein
UniProt Gene Name:
TRIM55Â Â
UniProt Entry Name:
TRI55_HUMAN
Western blot analysis of extracts of various cell lines, using TRIM55 antibody (CAB15917) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
