The TRIM5 Polyclonal Antibody (CAB17234) is a valuable tool for researchers studying TRIM5, a protein involved in innate immune responses against retroviruses. This antibody, raised in rabbits, is highly specific to TRIM5 and is validated for use in various applications such as Western blot and immunofluorescence.TRIM5, a tripartite motif-containing protein, acts as a restriction factor against retroviral infections by targeting the viral capsid. It has been implicated in the host defense mechanism against HIV and other retroviruses, making it a key target for investigation in virology and immunology research.
By using the TRIM5 Polyclonal Antibody, researchers can detect and quantify TRIM5 protein levels in different cell types and tissues, providing valuable insights into its function and potential therapeutic applications in antiviral strategies. This antibody is essential for the study of TRIM5-mediated antiviral immunity and the development of novel treatments for retroviral infections.
Product Name:
TRIM5 Rabbit Polyclonal Antibody
SKU:
CAB17234
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TRIM5 (NP_149083.2).
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
85363
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRIM5 Rabbit pAb (CAB17234) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
