The Trim5 Polyclonal Antibody (CAB1872) is a valuable tool for research involving the Trim5 protein, a key player in the innate immune response against retroviruses. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the Trim5 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in virology and infectious disease research.Trim5 is a restriction factor that acts as a barrier to retroviral infections by targeting the viral capsid protein and inhibiting viral replication.
Understanding the mechanisms by which Trim5 functions is crucial for developing novel antiretroviral therapies and vaccines. The Trim5 Polyclonal Antibody provides researchers with a reliable tool to investigate the role of Trim5 in host defense against retroviruses, ultimately contributing to the development of new strategies for combating viral infections.
Product Name:
TRIM5 Rabbit Polyclonal Antibody
SKU:
CAB1872
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TRIM5 (NP_149083.2).
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
85363
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRIM5 Rabbit pAb (CAB1872) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
