TRIM40 Antibody (PACO20359)
- SKU:
- PACO20359
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | TRIM40 Antibody (PACO20359) |
| Antibody SKU: | PACO20359 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human TRIM40 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20359(TRIM40 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20359(TRIM40 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the tripartite motif (TRIM) protein family. The encoded protein may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract. Alternatively spliced transcript variants that encode different protein isoforms have been described. |
| Synonyms: | tripartite motif containing 40 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015] |
| UniProt Code: | Q6P9F5 |
| NCBI GenInfo Identifier: | 20162564 |
| NCBI Gene ID: | 54894 |
| NCBI Accession: | NP_619645 |
| UniProt Secondary Accession: | Q6P9F5,Q6P9F5 |
| UniProt Related Accession: | Q6P9F5,Q68DV7 |
| Molecular Weight: | 86 |
| NCBI Full Name: | tripartite motif-containing protein 40 isoform b |
| NCBI Synonym Full Names: | ring finger protein 43 |
| NCBI Official Symbol: | RNF43Â Â |
| NCBI Official Synonym Symbols: | URCC; SSPCS; RNF124Â Â |
| NCBI Protein Information: | E3 ubiquitin-protein ligase RNF43 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase RNF43 |
| UniProt Synonym Protein Names: | RING finger protein 43 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | RNF43Â Â |
| UniProt Entry Name: | RNF43_HUMAN |
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