The Trim37 Polyclonal Antibody (CAB18307) is a valuable tool for researchers studying Trim37, a protein involved in the regulation of cell growth and division. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the Trim37 protein, this antibody allows for the detection and analysis of Trim37 expression in various cell types, making it an ideal reagent for studies in cell biology and cancer research.Trim37, a member of the Tripartite Motif (TRIM) protein family, is known to play a role in regulating cell proliferation and maintaining genomic stability.
Dysregulation of Trim37 expression has been linked to various human cancers, making it a potential therapeutic target for cancer treatment. By understanding the function of Trim37, researchers can gain insights into the mechanisms underlying tumorigenesis and potentially develop novel strategies for cancer therapy. The Trim37 Polyclonal Antibody is a valuable tool for advancing research in this area and uncovering the role of Trim37 in cellular processes and disease pathogenesis.
Product Name:
TRIM37 Rabbit Polyclonal Antibody
SKU:
CAB18307
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 735-964 of human TRIM37 (NP_001005207.1).
cytoplasm, cytosol, perinuclear region of cytoplasm, peroxisome
Calculated MW:
108kDa
Observed MW:
135kDa
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders.
Purification Method:
Affinity purification
Gene ID:
4591
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRIM37 Rabbit pAb (CAB18307) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
