TRIM34 Antibody (PACO20356)
- SKU:
- PACO20356
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
TRIM34 Antibody (PACO20356)
The TRIM34 Polyclonal Antibody (PAC020356) is a valuable tool for researchers studying TRIM34, a protein involved in immune regulation and signaling pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to TRIM34, this antibody enables the detection and analysis of TRIM34 expression in various cell types, making it ideal for studies in immunology and cancer research.
TRIM34, a member of the TRIM family of proteins, is known to play a role in immune response regulation by modulating signaling pathways and protein degradation. Its involvement in immune function suggests its potential relevance to diseases such as cancer, autoimmune disorders, and infectious diseases. Research on TRIM34 can provide insights into the mechanisms of immune regulation and potential therapeutic targets for immunomodulation in various disease contexts.
| Antibody Name: | TRIM34 Antibody (PACO20356) |
| Antibody SKU: | PACO20356 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human TRIM34 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20356(TRIM34 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Jurkat cells, Primary antibody: PACO20356(TRIM34 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20356(TRIM34 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. |
| Synonyms: | tripartite motif containing 34 |
| UniProt Protein Function: | TRIM34: is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 11p15Cellular Component: cytoplasm; cytosolBiological Process: positive regulation of transcription factor activity |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q9BYJ4 |
| NCBI GenInfo Identifier: | 55976584 |
| NCBI Gene ID: | 53840 |
| NCBI Accession: | Q9BYJ4.2 |
| UniProt Secondary Accession: | Q9BYJ4,Q9C016, Q9HCR0, Q9HCR1, Q9HCR2, D3DQS7 |
| UniProt Related Accession: | Q9BYJ4 |
| Molecular Weight: | 31,338 Da |
| NCBI Full Name: | Tripartite motif-containing protein 34 |
| NCBI Synonym Full Names: | tripartite motif containing 34 |
| NCBI Official Symbol: | TRIM34Â Â |
| NCBI Official Synonym Symbols: | IFP1; RNF21Â Â |
| NCBI Protein Information: | tripartite motif-containing protein 34 |
| UniProt Protein Name: | Tripartite motif-containing protein 34 |
| UniProt Synonym Protein Names: | Interferon-responsive finger protein 1; RING finger protein 21 |
| Protein Family: | Tripartite motif-containing protein |
| UniProt Gene Name: | TRIM34Â Â |
| UniProt Entry Name: | TRI34_HUMAN |
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