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TRIM3 Antibody (PACO02345)

SKU:
PACO02345
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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TRIM3 Antibody (PACO02345)

The TRIM3 Polyclonal Antibody (PACO02345) is a valuable tool for researchers studying the TRIM3 protein, a member of the tripartite motif (TRIM) family that plays a role in various cellular processes. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is optimized for Western blot applications. By specifically binding to TRIM3, this antibody enables accurate detection and analysis of the protein in a variety of cell types, making it an excellent choice for investigations in molecular biology and neuroscience.

TRIM3 is known for its involvement in neuronal development and synaptic function, making it a key player in neurological disorders and neurodegenerative diseases. By targeting TRIM3, researchers can gain insights into its functions and potential therapeutic strategies for conditions such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. The TRIM3 Polyclonal Antibody is a valuable tool for uncovering the roles of TRIM3 in these contexts and advancing our understanding of neurobiology.

Antibody Name:TRIM3 Antibody
Antibody SKU:PACO02345
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the N-terminal region of human TRIM3.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:TRIM3; BERP; RNF22; RNF97; Tripartite motif-containing protein 3; Brain-expressed RING finger protein; RING finger protein 22; RING finger protein 97
UniProt Protein Function:TRIM3: Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Belongs to the TRIM/RBCC family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytoskeletal; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytoplasm; early endosome

Molecular Function:protein C-terminus binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity

Biological Process: nervous system development; protein transport; protein ubiquitination

NCBI Summary:The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:O75382
NCBI GenInfo Identifier:351721563
NCBI Gene ID:10612
NCBI Accession:NP_001234935.1
UniProt Secondary Accession:O75382,Q4V9L4, Q9C038, Q9C039, B7Z5E6, F5H2Q8,
UniProt Related Accession:O75382
Molecular Weight:80,830 Da
NCBI Full Name:tripartite motif-containing protein 3 isoform 1
NCBI Synonym Full Names:tripartite motif containing 3
NCBI Official Symbol:TRIM3  
NCBI Official Synonym Symbols:BERP; HAC1; RNF22; RNF97  
NCBI Protein Information:tripartite motif-containing protein 3; RING finger protein 97; ring finger protein 22; brain expressed ring finger; tripartite motif-containing 3; tripartite motif protein TRIM3; brain-expressed RING finger protein
UniProt Protein Name:Tripartite motif-containing protein 3
UniProt Synonym Protein Names:Brain-expressed RING finger protein; RING finger protein 22; RING finger protein 97
Protein Family:Tripartite motif-containing protein
UniProt Gene Name:TRIM3  
UniProt Entry Name:TRIM3_HUMAN

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