The TRIM21 SS-A Monoclonal Antibody (CAB24737) is a valuable tool for researchers studying TRIM21, a protein involved in immune response and autoimmunity. This monoclonal antibody, produced using hybridoma technology, specifically targets TRIM21 and has been validated for use in various applications, including immunoprecipitation and immunofluorescence.TRIM21, also known as Ro52, is a cytosolic antibody receptor that plays a key role in the immune system's response to viral infections and autoimmune diseases. By targeting antibodies bound to viral particles, TRIM21 facilitates the destruction of these pathogens within cells.
Additionally, TRIM21 has been implicated in autoimmune conditions, making it a promising target for further research in areas such as rheumatology and immunology.Researchers studying TRIM21 can utilize the CAB24737 Monoclonal Antibody to detect and analyze TRIM21 expression in cell samples, providing valuable insights into its function and potential therapeutic applications. With its high specificity and sensitivity, this antibody is an essential tool for advancing our understanding of immune response mechanisms and autoimmune disorders.
Product Name:
TRIM21/SS-A Monoclonal Antibody
SKU:
CAB24737
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant Protein corresponding to a sequence within amino acids 86-334 of human TRIM21 (NP_003361.1).
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
Purification Method:
Affinity purification
Gene ID:
6737
Clone Number:
ARC64169
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using TRIM21 Rabbit mAb (CAB24737) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
