The Trim21/SS-A Monoclonal Antibody (CAB22724) is a powerful tool for researchers studying Trim21, a protein involved in the immune response and autoimmune diseases. This monoclonal antibody was developed using advanced techniques to ensure high specificity and sensitivity in detecting Trim21 in various biological samples. Trim21, also known as Ro52, plays a crucial role in the immune system by targeting intracellular pathogens for degradation. It is also implicated in the development of autoimmune conditions, making it a promising target for therapeutic interventions.
The Trim21/SS-A antibody is validated for use in immunofluorescence, immunoprecipitation, and other immunoassays, enabling researchers to investigate the expression and function of Trim21 in different cell types and disease models.By using the Trim21/SS-A Monoclonal Antibody, researchers can gain valuable insights into the role of Trim21 in immune regulation and autoimmune diseases. This antibody is a valuable tool for advancing our understanding of the immune system and developing novel therapies for conditions related to immune dysfunction.
Product Name:
TRIM21/SS-A Monoclonal Antibody
SKU:
CAB22724
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 251-350 of human TRIM21/SS-A(NP_003132.2).
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
Purification Method:
Affinity purification
Gene ID:
6737
Clone Number:
ARC57363
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of HT-1080, using TRIM21/SS-A antibody (CAB22724) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
