The Trim21 Polyclonal Antibody (CAB1957) is a valuable tool for researchers studying Trim21, a cytoplasmic protein involved in immune response regulation. This antibody, produced in rabbits, is highly specific for human samples and is ideal for use in Western blot applications. By targeting the Trim21 protein, this antibody allows for precise detection and analysis of Trim21 expression in a variety of cell types, making it a useful tool in immunology and cancer research studies.Trim21, also known as Ro52, is a key player in the immune system, functioning as an E3 ubiquitin ligase and contributing to the regulation of inflammatory responses.
Research into Trim21's role in immune regulation is essential for understanding its potential as a therapeutic target for diseases such as cancer, autoimmune disorders, and chronic inflammation. By investigating Trim21 activity, researchers can gain insights into the mechanisms underlying these diseases and potentially develop new treatment strategies aimed at modulating immune function.
Product Name:
TRIM21 Rabbit Polyclonal Antibody
SKU:
CAB1957
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 86-334 of human TRIM21/SS-A (NP_003132.2).
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
Purification Method:
Affinity purification
Gene ID:
6737
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung using TRIM21/SS-A Rabbit pAb(CAB1957) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:180s.
