The Trim21 Polyclonal Antibody (CAB13547) is a valuable tool for researchers studying Trim21, a cytosolic antibody receptor involved in immune defense against viral infections. This antibody, produced in rabbits, is highly specific for Trim21 in human samples and is validated for use in various applications, including Western blotting.Trim21, also known as Ro52, plays a crucial role in the innate immune response by targeting viral particles for degradation. Its ability to recognize and neutralize pathogens makes it an essential component of the antiviral defense mechanism.
By targeting Trim21, researchers can gain insights into how the immune system responds to viral infections and develop potential therapeutics to enhance immune defense.With its high reactivity and specificity, the Trim21 Polyclonal Antibody is an excellent choice for studies in virology, immunology, and infectious diseases. By enabling the detection and analysis of Trim21 in different cell types, this antibody facilitates research aimed at understanding the mechanisms underlying immune defense and advancing the development of novel antiviral therapies.
Product Name:
TRIM21 Rabbit Polyclonal Antibody
SKU:
CAB13547
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 86-334 of human TRIM21/SS-A (NP_003132.2).
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
Purification Method:
Affinity purification
Gene ID:
6737
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRIM21/SS-A Rabbit pAb (CAB13547) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
