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Trim21 Antibody (PACO36614)

SKU:
PACO36614
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€359
Frequently bought together:

Description

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Trim21 Antibody (PACO36614)

The Trim21 Polyclonal Antibody (PACO36614) is a valuable tool for researchers studying Trim21, a cytosolic antibody receptor known for its role in antiviral immune responses. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By targeting the Trim21 protein, this antibody enables precise detection and characterization of Trim21 in a variety of cell types, making it an essential tool for investigations in virology and immunology.Trim21, also known as Ro52, is a key player in the cellular defense against viral infections by promoting the degradation of virus particles.

Its unique mechanism of action and its ability to trigger immune responses make it a promising target for the development of antiviral therapies. Research on Trim21 is important for understanding host-pathogen interactions and for designing strategies to combat viral infections effectively.By using the Trim21 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of Trim21, ultimately advancing our knowledge of antiviral immunity and potentially leading to the development of novel antiviral treatments.

Antibody Name:Trim21 Antibody (PACO36614)
Antibody SKU:PACO36614
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse E3 ubiquitin-protein ligase TRIM21 protein (1-470AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-β production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.
Synonyms:E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING-type E3 ubiquitin transferase TRIM21) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21), Trim21, Ro52 Ssa1
UniProt Protein Function:TRIM21: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B ('Thr- 187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin- mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligaseChromosomal Location of Human Ortholog: 7|7 E3Cellular Component: cytoplasm; nucleoplasm; nucleus; SCF ubiquitin ligase complexMolecular Function: identical protein binding; protein binding; ubiquitin-protein ligase activityBiological Process: inhibition of NF-kappaB transcription factor; innate immune response; negative regulation of viral transcription; positive regulation of autophagy; positive regulation of cell cycle; positive regulation of transcription factor activity; positive regulation of virion penetration into host cell; protein autoubiquitination; protein destabilization; protein monoubiquitination; protein polyubiquitination; protein ubiquitination
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q62191
NCBI GenInfo Identifier:3024571
NCBI Gene ID:20821
NCBI Accession:Q62191.1
UniProt Secondary Accession:Q62191
UniProt Related Accession:Q62191
Molecular Weight:70.2 kDa
NCBI Full Name:E3 ubiquitin-protein ligase TRIM21
NCBI Synonym Full Names:tripartite motif-containing 21
NCBI Official Symbol:Trim21  
NCBI Official Synonym Symbols:Ro52; Ssa1  
NCBI Protein Information:E3 ubiquitin-protein ligase TRIM21
UniProt Protein Name:E3 ubiquitin-protein ligase TRIM21
UniProt Synonym Protein Names:52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; RING-type E3 ubiquitin transferase TRIM21Curated; Ro(SS-A); Sjoegren syndrome type A antigen; SS-A; Tripartite motif-containing protein 21
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:Trim21  
UniProt Entry Name:

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