The TRIM2 Polyclonal Antibody (CAB14393) is a valuable tool for researchers studying the TRIM2 protein, a member of the tripartite motif-containing (TRIM) family involved in various cellular processes, including protein degradation and innate immune response. This antibody, generated in rabbits, is highly specific for human TRIM2 and has been validated for use in Western blot applications.TRIM2 is known to play a role in neurodegenerative diseases, such as Parkinson's disease and Amyotrophic Lateral Sclerosis (ALS), by promoting the degradation of misfolded proteins and maintaining cellular homeostasis.
By targeting TRIM2 with this antibody, researchers can investigate its function in neurological disorders and potentially identify new therapeutic targets for treatment.Overall, the TRIM2 Polyclonal Antibody is a reliable tool for exploring the role of TRIM2 in cellular processes and neurodegenerative diseases, allowing for deeper insights into the molecular mechanisms underlying these conditions.
Product Name:
TRIM2 Rabbit Polyclonal Antibody
SKU:
CAB14393
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human TRIM2 (NP_056086.2).
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
23321
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse small intestine, using TRIM2 Rabbit pAb (CAB14393) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
