The TRIM14 Polyclonal Antibody (PAC020690) is a valuable tool for research involving TRIM14, a protein with important functions in the immune response and inflammation. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the TRIM14 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.TRIM14, also known as a potent regulator of innate immunity, plays a crucial role in the antiviral response and inflammatory signaling.
Its involvement in immune activation and modulation makes it a key player in research related to infectious diseases, cancer, and autoimmune disorders. Understanding the function of TRIM14 is essential for developing targeted therapies that can manipulate immune responses in these disease contexts.Overall, the TRIM14 Polyclonal Antibody (PAC020690) is a reliable tool for researchers seeking to investigate the roles of TRIM14 in immune regulation and inflammatory processes, with potential implications for the development of novel therapeutic strategies.
Antibody Name:
TRIM14 Antibody (PACO20690)
Antibody SKU:
PACO20690
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human TRIM14
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20690(TRIM14 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants.
Synonyms:
tripartite motif containing 14
UniProt Protein Function:
TRIM14: Inhibits the transcriptional activity of SPI1 in a dose- dependent manner. Belongs to the TRIM/RBCC family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 9q22.33Cellular Component: cytoplasm; intracellularMolecular Function: zinc ion bindingBiological Process: negative regulation of viral transcription; innate immune response; positive regulation of transcription factor activity; activation of NF-kappaB transcription factor
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
