The TRIM14 Polyclonal Antibody (PACO17254) is a valuable tool for researchers studying TRIM14, a protein known for its involvement in immune responses and antiviral defense mechanisms. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding specifically to the TRIM14 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for investigations in immunology and virology research.TRIM14 is a key player in the innate immune response, functioning as a pattern recognition receptor that recognizes viral nucleic acids and activates antiviral signaling pathways.
Its role in modulating immune responses and promoting antiviral defenses highlights its importance in understanding host-pathogen interactions and developing novel therapeutic strategies for viral infections. The TRIM14 Polyclonal Antibody is a valuable tool for researchers seeking to unravel the complexities of innate immunity and explore new avenues for combating viral diseases.
Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: PACO17254(TRIM14 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17254(TRIM14 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants.
Synonyms:
tripartite motif containing 14
UniProt Protein Function:
TRIM14: Inhibits the transcriptional activity of SPI1 in a dose- dependent manner. Belongs to the TRIM/RBCC family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 9q22.33Cellular Component: cytoplasm; intracellularMolecular Function: zinc ion bindingBiological Process: negative regulation of viral transcription; innate immune response; positive regulation of transcription factor activity; activation of NF-kappaB transcription factor
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
