The Tribbles Homolog 2 Polyclonal Antibody (CAB11661) is a valuable tool for researchers studying the Tribbles Homolog 2 protein, which is involved in various cellular processes, including cell proliferation, apoptosis, and inflammation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.Tribbles Homolog 2 has been implicated in cancer progression, immune response regulation, and metabolic disorders, making it a promising target for therapeutic interventions. By detecting and analyzing the Tribbles Homolog 2 protein in different cell types, researchers can gain insights into its role in disease development and progression, paving the way for the development of novel treatment strategies.
The Tribbles Homolog 2 Polyclonal Antibody is a versatile tool for studies in oncology, immunology, and metabolic research, enabling researchers to further understand the molecular mechanisms underlying disease pathogenesis and identify potential therapeutic targets. Its high reactivity and specificity make it an essential component of any research program focused on Tribbles Homolog 2 and its role in disease biology.
Product Name:
TRIB2 Rabbit Polyclonal Antibody
SKU:
CAB11661
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human TRIB2 (NP_067675.1).
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
28951
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRIB2 Rabbit pAb (CAB11661) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
