The TRIB1 Antibody (PAC020762) is a polyclonal antibody designed for research involving TRIB1, a protein that plays a crucial role in various biological processes such as cell proliferation, differentiation, and inflammation. The antibody, generated in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding to the TRIB1 protein, this antibody enables researchers to detect and analyze TRIB1 expression in different cell types, making it a valuable tool for studies in immunology, cancer research, and beyond.
TRIB1 is a key player in intracellular signaling pathways and is known to regulate genes involved in lipid metabolism, inflammation, and cell cycle progression. Dysregulation of TRIB1 has been linked to various diseases including cancer, cardiovascular diseases, and metabolic disorders. Understanding the function of TRIB1 is essential for unraveling its role in disease pathogenesis and may lead to the development of novel therapeutic strategies targeting this protein.
Antibody Name:
TRIB1 Antibody (PACO20762)
Antibody SKU:
PACO20762
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human TRIB1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20762(TRIB1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.
Synonyms:
tribbles pseudokinase 1
UniProt Protein Function:
TRB1: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
UniProt Protein Details:
Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CAMK; CAMK group; Trbl family
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component: cytoplasm; nucleus
Molecular Function:ATP binding; mitogen-activated protein kinase kinase binding; protein binding; protein kinase activity; protein kinase inhibitor activity; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity
Biological Process: JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of protein kinase activity; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; negative regulation of transcription factor activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of MAP kinase activity; response to lipopolysaccharide
