The TRIB1 Polyclonal Antibody (PAC020761) is specifically designed for research involving TRIB1, a protein known to play a role in various cellular processes, including lipid metabolism and inflammation. The antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. It binds specifically to the TRIB1 protein, allowing for precise detection and analysis in a variety of cell types, making it an ideal tool for studies in metabolism, inflammation, and cardiovascular diseases.
TRIB1 is a key player in the regulation of lipid metabolism and has been implicated in the development of atherosclerosis and other metabolic disorders. Its role in inflammation also makes it a potential target for research in conditions such as obesity, diabetes, and cardiovascular diseases. Understanding the function of TRIB1 is crucial for developing targeted therapies to combat these diseases and improve overall health outcomes.
Antibody Name:
TRIB1 Antibody (PACO20761)
Antibody SKU:
PACO20761
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human TRIB1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20761(TRIB1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20761(TRIB1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.
Synonyms:
tribbles pseudokinase 1
UniProt Protein Function:
TRB1: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
UniProt Protein Details:
Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CAMK; CAMK group; Trbl family
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component: cytoplasm; nucleus
Molecular Function:ATP binding; mitogen-activated protein kinase kinase binding; protein binding; protein kinase activity; protein kinase inhibitor activity; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity
Biological Process: JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of protein kinase activity; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; negative regulation of transcription factor activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of MAP kinase activity; response to lipopolysaccharide
