The TRH Polyclonal Antibody (CAB14472) is a valuable tool for research involving the thyrotropin-releasing hormone (TRH) receptor. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it suitable for a variety of experimental applications.TRH is a neurotransmitter that plays a key role in the regulation of the hypothalamic-pituitary-thyroid axis, controlling the release of thyroid-stimulating hormone (TSH) from the pituitary gland. The TRH receptor is a G protein-coupled receptor that mediates the effects of TRH in various physiological processes, including the regulation of metabolism, energy balance, and stress responses.With its ability to bind to the TRH receptor protein, the CAB14472 antibody enables the detection and analysis of TRH receptor expression in different cell types and tissues.
This makes it an essential tool for studies investigating the role of TRH signaling in thyroid function, metabolism, and neuroendocrine regulation.Overall, the TRH Polyclonal Antibody (CAB14472) is a reliable reagent for researchers interested in unraveling the complex mechanisms underlying TRH receptor function and its implications in various physiological and pathological conditions. Its high specificity and sensitivity make it a valuable asset in furthering our understanding of TRH signaling pathways and developing potential therapeutic interventions targeting this important neurotransmitter system.
Product Name:
TRH Rabbit Polyclonal Antibody
SKU:
CAB14472
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 143-242 of human TRH (NP_009048.1).
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism.
Purification Method:
Affinity purification
Gene ID:
7200
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRH Rabbit pAb (CAB14472) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
