The TREX1 Rabbit Monoclonal Antibody (CAB3819) is a specialized tool for researchers studying TREX1, a key enzyme involved in DNA metabolism and immune regulation. This antibody is produced in rabbits and is highly specific for detecting TREX1 in human samples, making it an essential tool for studies in immunology and cancer research. TREX1 is known for its role in DNA degradation and its involvement in autoimmune diseases such as Aicardi-Goutières syndrome and systemic lupus erythematosus. By targeting TREX1, researchers can better understand its functions in maintaining genome stability and modulating immune responses, leading to potential insights for therapeutic interventions in various disease conditions.
With its high reactivity and validation for Western blot applications, the TREX1 Rabbit Monoclonal Antibody (CAB3819) enables precise detection and analysis of TREX1 protein levels in different cell types. This antibody is a valuable resource for scientists looking to explore the intricate mechanisms of TREX1 and its implications in health and disease.
Product Name:
TREX1 Rabbit Monoclonal Antibody
SKU:
CAB3819
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 150-314 of human TREX1 (Q9NSU2).
This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
11277
Clone Number:
ARC0841
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TREX1 Rabbit mAb (CAB3819) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
