The TREX1 Polyclonal Antibody (CAB6778) is a valuable tool for researchers studying the TREX1 protein, which is involved in DNA degradation and regulation of immune responses. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TREX1 protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for studies in immunology, autoimmunity, and cancer research.TREX1, also known as DNase III, plays a crucial role in maintaining genomic stability by clearing out DNA fragments that can trigger inflammatory responses.
Dysregulation of TREX1 has been linked to autoimmune diseases such as Aicardi-Goutières syndrome and systemic lupus erythematosus, highlighting its importance in immune system function. By understanding the role of TREX1 in immune regulation, researchers can potentially develop targeted therapies for autoimmune disorders and other inflammatory conditions.
Product Name:
TREX1 Rabbit Polyclonal Antibody
SKU:
CAB6778
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human TREX1 (NP_057465.1).
This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
11277
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TREX1 antibody (CAB6778) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
