The TREM2 Monoclonal Antibody (CAB23432) is a versatile tool for researchers studying TREM2, a cell surface receptor involved in immune response and neuroinflammation. This antibody, produced using monoclonal technology, exhibits high specificity and sensitivity in detecting TREM2 in human samples, making it an essential component in Western blot and immunohistochemistry assays.TREM2, or triggering receptor expressed on myeloid cells 2, plays a crucial role in the regulation of immune responses and phagocytosis by microglia in the central nervous system.
Dysregulation of TREM2 has been linked to several neurodegenerative diseases, including Alzheimer's disease and multiple sclerosis, making it a promising target for therapeutic interventions.By using the TREM2 Monoclonal Antibody, researchers can gain valuable insights into the function and expression of TREM2 in various cell types and disease models. This antibody's ability to specifically bind to TREM2 enables precise detection and quantification, facilitating studies in neuroimmunology, neurodegenerative diseases, and immunotherapy development.
Product Name:
TREM2 Monoclonal Antibody
SKU:
CAB23432
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant protein of human TREM2.
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c; TREM2
Positive Sample:
Mouse heart
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
25kDa
Observed MW:
30kDa
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
54209
Clone Number:
ARC59142
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart, using TREM2 Rabbit mAb (CAB23432) at 1:8000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
