The TREM2 Monoclonal Antibody (CAB22134) is a powerful tool for research involving TREM2, a cell surface receptor associated with microglial function and neuroinflammation. This monoclonal antibody, produced in a lab setting, is highly specific to human TREM2 and has been validated for use in various experimental applications, including immunoprecipitation and flow cytometry.TREM2, short for triggering receptor expressed on myeloid cells 2, is known for its role in regulating the activity of microglia, the immune cells of the central nervous system. Dysregulation of TREM2 has been linked to neurodegenerative disorders such as Alzheimer's disease, making it a promising target for therapeutic interventions aimed at modulating neuroinflammation and neuronal damage.
By using the TREM2 Monoclonal Antibody, researchers can gain valuable insights into the function and expression of TREM2 in different biological contexts, paving the way for innovative approaches to understanding and potentially treating neuroinflammatory diseases. Its high specificity and reproducibility make it an essential tool for studies in neuroscience and immunology.
Product Name:
TREM2 Monoclonal Antibody
SKU:
CAB22134
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-161 of human TREM2 (NP_061838.1).
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
54209
Clone Number:
ARC55114
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HUH-7, using TREM2 antibody (CAB22134) at 1:10000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
