The Treacle Protein Polyclonal Antibody (CAB2512) is a valuable tool for researchers studying the Treacle protein, a key player in cellular processes related to ribosome biogenesis and cell growth. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Treacle protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and cancer research.The Treacle protein, also known as TCOF1, is essential for proper ribosome formation and cell proliferation.
Mutations in the TCOF1 gene have been linked to Treacher Collins syndrome, a rare genetic disorder characterized by facial deformities. Research on the Treacle protein is crucial for understanding its role in normal cellular processes and its potential as a therapeutic target in diseases like cancer and developmental disorders.By providing a reliable tool for detecting and studying the Treacle protein, the Treacle Protein Polyclonal Antibody (CAB2512) contributes to advances in biomedical research and the development of targeted therapies for Treacle-related diseases.
Product Name:
TCOF1 Rabbit Polyclonal Antibody
SKU:
CAB2512
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 659-958 of human TCOF1 (NP_001008657.1).
This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6949
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using TCOF1 Rabbit pAb (CAB2512) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
