The TRCP/BTRC Monoclonal Antibody is a cutting-edge tool designed for researchers studying the TRCP/BTRC protein, a critical component in the regulation of cellular processes such as cell cycle progression and DNA replication. This antibody, produced through monoclonal technology, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blotting and immunofluorescence applications.TRCP/BTRC, also known as beta-transducin repeat containing protein, is a key player in the degradation of various proteins involved in cell growth and division. Dysregulation of TRCP/BTRC has been linked to cancer development, making it a promising target for therapeutic interventions.
By utilizing this antibody, researchers can gain valuable insights into the function and regulation of TRCP/BTRC, paving the way for new advancements in cancer research and drug discovery.Unlock the potential of TRCP/BTRC research with the TRCP/BTRC Monoclonal Antibody, and explore the intricate mechanisms underlying cell cycle control and tumorigenesis. Accelerate your studies and make groundbreaking discoveries in the field of molecular biology with this innovative antibody tool.
Product Name:
β-TrCP/BTRC Monoclonal Antibody
SKU:
CAB21951
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human β-TrCP/BTRC (NP_378663.1).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.
Purification Method:
Affinity purification
Gene ID:
8945
Clone Number:
ARC51997
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from C2C12 cells, using β-TrCP/BTRC Rabbit mAb (CAB21951) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
