The TRAPPC11 Polyclonal Antibody (PAC050746) is a valuable tool for researchers studying TRAPPC11, a vital protein involved in intracellular trafficking and vesicle transport processes. This antibody, produced in rabbits, exhibits high specificity towards human samples and has been validated for use in Western blot applications. By targeting the TRAPPC11 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential asset for investigations in cell biology and neurology research.
TRAPPC11, a subunit of the TRAPP complex, plays a crucial role in coordinating vesicle budding and tethering events required for proper protein transport within cells. Dysregulation of TRAPPC11 function has been linked to various neurological disorders and vesicle trafficking-related diseases. By studying the function and regulation of TRAPPC11, researchers can gain insights into the underlying mechanisms of these conditions and potentially identify therapeutic targets for novel treatment strategies.
Antibody Name:
TRAPPC11 Antibody (PACO50746)
Antibody SKU:
PACO50746
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Trafficking protein particle complex subunit 11 protein (704-836AA)
Immunofluorescence staining of U251 cells with PACO50746 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)..
Background:
Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
Synonyms:
Trafficking protein particle complex subunit 11, TRAPPC11, C4orf41
UniProt Protein Function:
TRAPPC11: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Belongs to the TRAPPC11 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 4q35.1Cellular Component: Golgi apparatusBiological Process: vesicle-mediated transportDisease: Muscular Dystrophy, Limb-girdle, Type 2s
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]
