The Transcobalamin-2 Polyclonal Antibody (CAB5755) is a powerful tool for researchers studying transcobalamin-2, a protein involved in the transport of vitamin B12 into cells. This antibody, produced through immunization of rabbits, exhibits high reactivity with human samples and is validated for use in Western blotting applications.Transcobalamin-2 plays a crucial role in vitamin B12 uptake and utilization, making it essential for various cellular processes including DNA synthesis and nerve function. Dysregulation of transcobalamin-2 has been linked to vitamin B12 deficiency and related health conditions, highlighting its importance in human health.
By specifically binding to transcobalamin-2, this antibody enables precise detection and analysis of the protein in different cell types, making it an ideal tool for studies in biochemistry, nutrition, and metabolism. Understanding the function and regulation of transcobalamin-2 is key to developing targeted therapies for diseases related to vitamin B12 deficiency, such as anemia and neurological disorders.
Product Name:
TCN2 Rabbit Polyclonal Antibody
SKU:
CAB5755
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-250 of human TCN2 (NP_001171655.1).
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6948
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TCN2 antibody (CAB5755) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
