The Transaldolase Polyclonal Antibody (CAB6762) is a valuable tool for researchers studying transaldolase, an enzyme involved in the pentose phosphate pathway essential for cellular energy production. This antibody, produced in rabbits, is highly specific for human samples, making it ideal for Western blot applications to detect and analyze transaldolase protein levels.Transaldolase plays a crucial role in metabolizing sugars and generating NADPH, which is important for maintaining cellular redox balance and protecting against oxidative stress. Dysregulation of transaldolase has been linked to various diseases, including cancer and metabolic disorders.
Therefore, investigating the expression and activity of transaldolase can provide insights into these pathological conditions and potentially lead to the development of targeted therapies.By using the Transaldolase Polyclonal Antibody (CAB6762), researchers can further explore the functions and regulatory mechanisms of transaldolase in various cell types and tissues, advancing our understanding of its role in health and disease. This antibody serves as a valuable tool for studies in biochemistry, metabolism, and cell biology, offering new opportunities for therapeutic interventions in conditions associated with transaldolase dysfunction.
Product Name:
TALDO1 Rabbit Polyclonal Antibody
SKU:
CAB6762
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-337 of human TALDO1 (NP_006746.1).
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.
Purification Method:
Affinity purification
Gene ID:
6888
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TALDO1 antibody (CAB6762) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
