The TRAM2 Polyclonal Antibody (PACO35790) is a valuable tool for researchers studying TRAM2, a protein involved in the trafficking and processing of Toll-like receptors (TLRs) in innate immune responses. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. It effectively binds to TRAM2, enabling precise detection and analysis in various cell types, making it an excellent choice for immunology and infectious disease research.TRAM2 is an essential component in the signaling pathway of TLRs, which play a crucial role in recognizing pathogens and initiating immune responses.
Understanding the function of TRAM2 is key to deciphering the intricate mechanisms underlying innate immunity and inflammatory processes, with potential implications in the development of novel therapeutic strategies for infectious diseases and immunomodulation. Researchers investigating TLR-mediated signaling pathways and host defense mechanisms will greatly benefit from the use of this antibody in their studies.
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO35790 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO35790 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding.
Synonyms:
Translocating chain-associated membrane protein 2, TRAM2, KIAA0057
UniProt Protein Function:
TRAM2: Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Belongs to the TRAM family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6p21.1-p12Cellular Component: integral to membraneMolecular Function: protein bindingBiological Process: protein transport; collagen biosynthetic process
UniProt Protein Details:
NCBI Summary:
TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]
