The Tram2 Antibody (PACO12891) is a high-quality polyclonal antibody specifically designed for research involving Tram2, a protein involved in ER-Golgi transport and vesicle formation. This antibody, produced in rabbits, has been validated for use in various applications, including Western blotting, immunofluorescence, and immunoprecipitation.Tram2 is a crucial mediator of protein trafficking and secretion, making it a key player in cellular processes such as protein glycosylation and quality control. Dysfunction of Tram2 has been linked to various diseases, including neurodegenerative disorders and metabolic syndromes, making it a valuable target for research in these areas.
The Tram2 Antibody (PACO12891) enables the specific detection and analysis of Tram2 in various cell types, providing researchers with a powerful tool for investigating the role of Tram2 in health and disease. Its high reactivity with human samples and reliability in multiple applications make it an essential component for studies in cell biology, molecular biology, and drug discovery. Unlock the potential of Tram2 research with the Tram2 Antibody (PACO12891).
translocation associated membrane protein 2;TRAM2;KIAA0057 ;
UniProt Protein Function:
TRAM2: Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Belongs to the TRAM family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6p21.1-p12Cellular Component: integral to membraneMolecular Function: protein bindingBiological Process: protein transport; collagen biosynthetic process
UniProt Protein Details:
NCBI Summary:
TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]
