The TRAF6 Polyclonal Antibody (CAB16991) is a valuable tool for researchers studying TRAF6, a crucial protein involved in the regulation of inflammatory and immune responses. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.TRAF6, a member of the TNF receptor-associated factor (TRAF) family, is known for its role in mediating signaling pathways triggered by various receptors, including those involved in innate immune responses and inflammatory processes.
Its involvement in these pathways makes TRAF6 a key player in diseases such as cancer, autoimmune disorders, and inflammatory conditions.By utilizing the TRAF6 Polyclonal Antibody, researchers can effectively detect and analyze TRAF6 protein levels in different cell types, enabling a better understanding of its function in immune signaling pathways. This antibody is an essential tool for studies focusing on immunology, cancer biology, and inflammatory diseases where TRAF6 is implicated.
Product Name:
TRAF6 Rabbit Polyclonal Antibody
SKU:
CAB16991
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TRAF6 (NP_004611.1).
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in antiviral innate and antigen-specific immune responses.
Purification Method:
Affinity purification
Gene ID:
7189
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TRAF6 antibody (CAB16991) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
