The TRAF6 Polyclonal Antibody is a valuable tool for researchers studying the TRAF6 protein, which plays a crucial role in immune signaling pathways. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for Western blot applications. By binding to TRAF6, researchers can detect and analyze this protein in various cell types, enabling a better understanding of its function in immune responses.TRAF6 is known for its involvement in the regulation of inflammatory and immune responses, making it a key player in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
By targeting TRAF6, researchers can uncover potential therapeutic strategies for modulating immune function and combating these diseases effectively. This antibody is a valuable tool for immunology and cancer research, providing insights into the role of TRAF6 in immune regulation and disease pathogenesis.
Product Name:
TRAF6 Polyclonal Antibody
SKU:
CAB21637
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TRAF6 (NP_004611.1).
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in antiviral innate and antigen-specific immune responses.
Purification Method:
Affinity purification
Gene ID:
7189
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRAF6 Rabbit pAb (CAB21637) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
