The TRAF6 Polyclonal Antibody (CAB0973) is a valuable tool for researchers studying the TRAF6 protein, which plays a crucial role in immune signaling pathways. This antibody, generated in rabbits, is specifically designed to target TRAF6 in human samples and has been validated for use in Western blot applications. By binding to TRAF6, this antibody allows for accurate detection and analysis of the protein in various cell types, making it an essential component in immunological and cancer research studies.
TRAF6 is a key player in the regulation of immune responses, particularly in the activation of NF-κB and MAPK signaling pathways. Dysregulation of TRAF6 has been linked to autoimmune disorders, inflammatory diseases, and cancer, highlighting its importance as a therapeutic target. By studying the function of TRAF6 with this antibody, researchers can gain valuable insights into the molecular mechanisms underlying these conditions and potentially identify new avenues for treatment development.
Product Name:
TRAF6 Rabbit Polyclonal Antibody
SKU:
CAB0973
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human TRAF6 (NP_004611.1).
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in antiviral innate and antigen-specific immune responses.
Purification Method:
Affinity purification
Gene ID:
7189
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of HeLa cells using TRAF6 Rabbit pAb (CAB0973) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
