The TRAF4 Monoclonal Antibody is a crucial tool for researchers studying TRAF4, a key protein involved in immune signaling pathways. This antibody, produced using advanced monoclonal antibody technology, offers high specificity and sensitivity for detecting TRAF4 in various cell types and tissues.TRAF4, a member of the TRAF family of proteins, serves as a crucial mediator in immune responses, particularly in the regulation of cytokine production and cell survival. Dysregulation of TRAF4 has been implicated in various diseases, including cancer, inflammation, and autoimmune disorders.
By targeting TRAF4 with this monoclonal antibody, researchers can gain valuable insights into the molecular mechanisms underlying these conditions.This TRAF4 Monoclonal Antibody is suitable for a variety of applications, including Western blot, immunoprecipitation, and immunofluorescence, making it a versatile tool for investigating the role of TRAF4 in health and disease. Its high specificity and sensitivity ensure reliable results, making it an essential reagent for studies in immunology, cancer biology, and beyond.
Product Name:
TRAF4 Monoclonal Antibody
SKU:
CAB22472
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 209-470 of human TRAF4 (NP_004286.2).
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.
Purification Method:
Affinity purification
Gene ID:
9618
Clone Number:
ARC57454
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TRAF4 antibody (CAB22472) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
