TRAF2 Rabbit Monoclonal Antibody (CAB19129)
- SKU:
- CAB19129
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | TRAF2 Rabbit Monoclonal Antibody |
SKU: | CAB19129 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-350 of human TRAF2 (NP_066961.2). |
Sequence: | DGCG KKKI PREK FQDH VKTC GKCR VPCR FHAI GCLE TVEG EKQQ EHEV QWLR EHLA MLLS SVLE AKPL LGDQ SHAG SELL QRCE SLEK KTAT FENI VCVL NREV ERVA MTAE ACSR QHRL DQDK IEAL SSKV QQLE RSIG LKDL AMAD LEQK VLEM EAST Y |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:10000 - 1:60000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | TRAP; TRAP3; RNF117; MGC:45012; [KD Validated] TRAF2 |
Positive Sample: | 293T,HeLa,C2C12,Mouse thymus,Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 53kDa/54kDa/55kDa/61kDa |
Observed MW: | 53kDa |
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
Purification Method: | Affinity purification |
Gene ID: | 7186 |
Clone Number: | ARC51292 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |