The KO Validated TRAF2 Polyclonal Antibody (CAB0962) is a research tool specifically designed for studying TRAF2, a key protein involved in the regulation of immune and inflammatory responses. This polyclonal antibody is generated from rabbits and has been validated for use in Western blot applications with human samples. TRAF2, also known as tumor necrosis factor receptor-associated factor 2, is a crucial signaling molecule in various cellular processes, including cell survival, proliferation, and immune responses. By binding to TRAF2, this antibody enables precise detection and analysis of TRAF2 expression in different cell types, making it an invaluable tool for immunology and cancer research studies.
The role of TRAF2 in orchestrating immune responses and inflammatory signaling pathways underscores its importance as a potential therapeutic target for diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By elucidating the mechanisms by which TRAF2 functions, researchers can gain valuable insights into the development of novel therapeutic strategies aimed at modulating immune responses in various pathological contexts.
Product Name:
[KO Validated] TRAF2 Rabbit Polyclonal Antibody
SKU:
CAB0962
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human TRAF2 (NP_066961.2).
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
Purification Method:
Affinity purification
Gene ID:
7186
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRAF2 Rabbit pAb (CAB0962) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
