TRAF1 Rabbit Polyclonal Antibody (CAB0150)
- SKU:
- CAB0150
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | TRAF1 Rabbit Polyclonal Antibody |
SKU: | CAB0150 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 217-416 of human TRAF1 (NP_005649.1). |
Sequence: | TSIH QSQL DRER ILSL EQRV VELQ QTLA QKDQ ALGK LEQS LRLM EEAS FDGT FLWK ITNV TRRC HESA CGRT VSLF SPAF YTAK YGYK LCLR LYLN GDGT GKRT HLSL FIVI MRGE YDAL LPWP FRNK VTFM LLDQ NNRE HAID AFRP DLSS ASFQ RPQS ETNV ASGC PLFF PLSK LQSP KHAY VKDD TMFL KCIV ETST |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | EBI6; MGC:10353; TRAF1 |
Positive Sample: | SGC-7901,A-431,U-937,Jurkat,Mouse spleen,Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytoplasmic side of plasma membrane, cytosol |
Calculated MW: | 46kDa |
Observed MW: | 50kDa |
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 7185 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |