The TRADD Polyclonal Antibody (CAB18626) is a valuable tool for researchers studying TNF receptor-associated death domain (TRADD), a key component of the TNF receptor signaling pathway involved in immune response and cell survival. This antibody is raised in rabbits and is highly specific to human TRADD protein, making it ideal for Western blot applications.TRADD plays a crucial role in mediating cell death and survival signals in response to various extracellular stimuli, including cytokines and stress. Dysregulation of TRADD signaling has been implicated in a variety of diseases, including cancer, autoimmune disorders, and neurodegenerative conditions.
By targeting TRADD, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.This TRADD Polyclonal Antibody enables detection and analysis of TRADD protein in various cell types, facilitating research in immunology, oncology, and other fields. Its high specificity and sensitivity make it a reliable tool for studying TRADD function and its role in disease pathogenesis.
Product Name:
TRADD Rabbit Polyclonal Antibody
SKU:
CAB18626
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-312 of human TRADD (NP_003780.1).
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.
Purification Method:
Affinity purification
Gene ID:
8717
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRADD Rabbit pAb (CAB18626) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
