The TRADD Polyclonal Antibody (CAB1145) is a high-quality antibody designed for research involving TRADD, a key protein involved in regulating cell death pathways in response to various cellular stresses. This rabbit-derived antibody is highly specific to human samples and has been validated for use in Western blot applications.TRADD, or TNFRSF1A-associated via death domain, is a crucial mediator of cell death signaling pathways, particularly in response to tumor necrosis factor (TNF) receptor activation. Understanding the role of TRADD in cell death pathways is essential for unraveling the molecular mechanisms underlying conditions such as cancer, inflammation, and neurodegenerative diseases.
The TRADD Polyclonal Antibody binds specifically to TRADD protein, enabling researchers to detect and analyze its expression levels in different cell types and experimental conditions. This antibody is a valuable tool for investigating the intricate signaling events involved in cell death pathways and may lead to the development of novel therapeutic strategies targeting TRADD.
Product Name:
TRADD Rabbit Polyclonal Antibody
SKU:
CAB1145
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 199-312 of human TRADD (NP_003780.1).
Predicted to enable death domain binding activity; identical protein binding activity; and signaling receptor binding activity. Involved in positive regulation of hair follicle development. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in cytoplasm. Is expressed in adrenal gland; genitourinary system; liver; lung; and spleen. Orthologous to human TRADD (TNFRSF1A associated via death domain).
Purification Method:
Affinity purification
Gene ID:
8717
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from MCF7 cells, using TRADD Rabbit pAb (CAB1145) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
