The TR-1-THRB Monoclonal Antibody is a specialized antibody designed for research involving the THRB gene, which encodes the thyroid hormone receptor beta. This monoclonal antibody specifically targets the THRB protein, enabling accurate detection and analysis in various biological samples.Raised and purified in a controlled environment, this antibody offers high specificity and sensitivity, making it a reliable tool for studying the role of THRB in various cellular processes. It is validated for use in Western blot applications, allowing researchers to explore the expression levels and localization of THRB in different cell types.
The thyroid hormone receptor beta is a nuclear receptor that plays a critical role in mediating the effects of thyroid hormones on gene expression and metabolism. Dysregulation of THRB has been implicated in various diseases, including thyroid disorders, metabolic disorders, and certain types of cancer. By using the TR-1-THRB Monoclonal Antibody, researchers can gain valuable insights into the function of THRB and its potential therapeutic implications in these disease contexts.
Product Name:
TRβ1/THRB Monoclonal Antibody
SKU:
CAB22560
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-91 of human TRβ1/THRB (NP_000452.2).
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
7068
Clone Number:
ARC56361
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TRβ1/THRB antibody (CAB22560) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
