The TPT1 Polyclonal Antibody (PACO30762) is a valuable tool for researchers studying TPT1, a protein linked to cell growth, differentiation, and apoptosis. This antibody, generated in rabbits, has high specificity for human samples and has been validated for use in Western blot experiments. By binding specifically to TPT1, this antibody enables accurate detection and analysis of the protein in different cell types, making it ideal for investigations in cancer biology and cell signaling pathways.TPT1, also known as translationally controlled tumor protein, is a multifunctional protein involved in various cellular processes, including gene expression, cell cycle progression, and stress responses.
Dysregulation of TPT1 has been implicated in cancer development and progression, making it a promising target for therapeutic interventions. Understanding the role of TPT1 in cellular physiology is essential for developing targeted treatments for cancer and other diseases characterized by abnormal cell proliferation.Overall, the TPT1 Polyclonal Antibody is a valuable tool for researchers interested in unraveling the complex functions of TPT1 and its potential implications in health and disease. Its high specificity and reliability in Western blot applications make it an indispensable resource for studies aiming to elucidate the molecular mechanisms governing cellular growth and survival.
Antibody Name:
Tpt1 Antibody (PACO30762)
Antibody SKU:
PACO30762
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:10-1:100
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Translationally-controlled tumor protein (1-172AA)
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO30762 at dilution of 1:20.
Background:
Involved in calcium binding and microtubule stabilization.
Synonyms:
Translationally-controlled tumor protein (TCTP) (21 kDa polypeptide) (p21) (p23), Tpt1, Trt
UniProt Protein Function:
TPT1: a novel heat shock protein with antiapoptotic and chaperone-like activity. Its levels are highly regulated in response to various cellular stimuli and stresses. Downregulated in response to proapoptotic treatments that induce Ca(++) stress, in a PKR-dependent manner. Colocalizes with CHFR to the mitotic spindle. Appears to be involved in calcium binding and microtubule stabilization. Its exosomal secretion is induced following DNA damage. Interacts with MCL1 and STEAP3, a p53-inducible transmembrane protein that facilitates the exosomal secretion of TPT1. Secreted TPT1 acts as a histamine-releasing factor, participates in inflammatory responses by inducing the release of histamine, and may play a role in tumor reversion. May play a direct role in placental calcium transport. Phosphorylation by Plk may decrease its microtubule-stabilizing activity and promote microtubule dynamics following metaphase. Critical for peripheral T cell maintenance and TCR-mediated cell proliferation.Protein type: Calcium-binding; Microtubule-bindingCellular Component: cytoplasm; extracellular space; multivesicular body; nucleoplasm; nucleus; tubulin complexMolecular Function: calcium ion binding; microtubule binding; transcription factor bindingBiological Process: cell differentiation; stem cell maintenance
