Mast Cell Tryptase (TPSB2) Rabbit Polyclonal Antibody (CAB15887)
- SKU:
- CAB15887
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | Mast Cell Tryptase (TPSB2) Rabbit Polyclonal Antibody |
SKU: | CAB15887 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human Mast Cell Tryptase (Mast Cell Tryptase (TPSB2)) (NP_077078.5). |
Sequence: | MLNL LLLA LPVL ASRA YAAP APGQ ALQR VGIV GGQE APRS KWPW QVSL RVRD RYWM HFCG GSLI HPQW VLTA AHCV GPDV KDLA ALRV QLRE QHLY YQDQ LLPV SRII VHPQ FYTA QIGA DIAL LELE EPVN VSSH VHTV TLPP ASET FPPG MPCW VTGW GDVD NDER LPPP FPLK QVKV PIME NHIC DAKY HLGA YTGD DVRI VRDD MLCA GNTR RDSC QGDS GGPL VCKV NGTW LQAG VVSW GEGC AQPN RPGI YTRV TYYL DWIH HYVP KKP |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | TPS2; tryptaseB; tryptaseC; Mast Cell Tryptase (TPSB2) |
Positive Sample: | H-460,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 31kDa |
Observed MW: | 30kDa |
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Purification Method: | Affinity purification |
Gene ID: | 64499 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |